迟发性锥体外系综合征的危险因子分析

Tardive extrapyramidal syndrome (TES): risk factors analysis in a case-control study

抗精神病药物导致的迟发性锥体外系综合征（ＴＥＳ）由迟发性运动障碍（ＴＤ）发展而来。ＴＥＳ分ＴＤ、迟发性肌张力障碍（ＴＤＴ）等多个亚型，以ＴＤ最多见。ＴＥＳ的治疗无特效方法，因此预防尤为重要。本研究对上海地区七个精神病医疗单位进行普查，诊断ＴＥＳ１１３例，并采用病例－对照研究设计，对２３个相关因素进行Ｌｏｇｉｓｔｉｃ回归分析，推测ＴＥＳ的危险因子。结果发现，年龄、性别、抗胆碱能药物、用药总时间和目前用药量等五个因素在０．０５或０．０１水平上对ＴＥＳ的存在有显著意义上的作用。氯氮平、急性锥体外系统综合征还不能肯定为危险因子。

Neuroleptic- associated tardive extrapyramidal syndrome (TES) has been developed in the base of the tardive dyskinesia (TD). The subtypes of TES include TD, TDT, TA, TT, TM and TP. In the present study the subjects (TES) were drawn from seven psychiatric institutions in Shanghai and were assessed symptomatologically, analyzed by a design of the case-control study. Part of the data of the study were counted statistically by Logistic regression analysis with computer. It was found suggest that age, gender, anticholinergic drugs, treatment duration and current dosage as the risk factors have significant effects on the existence of TES at 0.05 or 0.01 level. Clozapine may have a complicated action on the onset of TES.