头孢泊肟酯合成研究Ⅰ．1－碘乙基异丙基碳酸酯的制备

A Synthesis Study of Cefpodoxime Proxetil Ⅰ. The Preparation of 1 Iodoethyl Isopropyl Carbonate

报道β－内酰胺类抗生素－头孢泊肟酯４位侧链中间体１－碘乙基异丙基碳酸酯的合成步骤，应用参数设计技术对１－氯乙基氯甲酸酯和１－氯乙基异丙基碳酸酯制备的工艺参数进行优化，收率分别达到５８．６％和７０％，均超过文献值，且简化了工艺，缩短了反应时间，易于工业化生产。

The synthesis steps of 1 iodoethyl isopropyl carbonate were reported. 1 Iodoethyl isopropyl carbonat is an intermedicate at the 4th position side chain of cefpodoxime Proxetil one of antibiotics of B lactams. A parameter design method was applied to select the optimum synthesis condtitons. 58.6% and 70% yields superior to the reported values for 1 iodoethyl chloroformate and 1 iodoethyl isopropyl carbonate were obtained respectively, and the process was also simplified and the reaction time reduced. It is easier to industrialize then.