若干手性药物的环糊精系统毛细管区带电泳拆分

Chiral Separation of Basic Drugs in Cyclodextrin Modified Capillry Zone Electrophorsis

在β－环糊精（β－ＣＤ）系统毛细管电泳（ＣＥ）中，成功地实现了一组常用药物的手性拆分。对实验结果和文献数据的分析表明，这一系统产生手性识别的内在原因是由疏水包结和氢键的综合效应所造成的络合作用差异，而β－ＣＤ浓度和有机添加剂则通过上述内在原因对手性拆分产生重要影响。

Seven typical enatiomeric drugs were successfully separated using a cyclodextrin modified CE system. Acidic buffer(pH 2 5) with cyclodextrin was used. Our results suggested that the basic reason of chiral recognition was the difference in the complexation of both enantiomers, resulting from the difference in hydrophobic affinity and in hydrogen bonding between the analyte and cyclodextrin. The important effects of variation of β CD concentration, organic additives, electroosmotic flow(EOF) were recognized by changing the parameters mentioned above .