非铂类金属抗肿瘤药物的研究进展

Progress on the Study of Non-Platinum Metallic Drugs in Antitumor

自从顺铂被发现具有抗肿瘤活性以来,金属抗肿瘤药物得到了飞速的发展,一些非铂类金属的化合物也相继被发现具有一定的抗肿瘤活性。与铂类金属药物相比,非铂类金属抗肿瘤药物的发展相对缓慢,但也取得了一定的成果。本文主要就一些已经进入临床试验阶段的非铂类抗肿瘤药物的研究进展作一简述。

Since cis-platin has been discovered showing antitumor activity, metallic antitumor agents have been widely investigated. Some non-platinum metallic compounds have also been found to possess antitumor properties, and quite a number of interesting and promising results have been achieved although the exploration of these compounds is at a slow pace compared to the platinum agents. This review mainly outlines the progress of the non-platinum metallic antitumor drugs in clinical trials.