清开灵对戊四氮致痫大鼠抗痫作用的研究

A study of interventional effects of Qingkailing on the behavior and electroencephalography of experimental epileptic rats induced by pentylenetetrazol

目的:通过观察清开灵对癫痫大鼠行为及脑电图的影响,了解其抗痫作用,为临床治疗癫痫提供理论依据。方法:采用戊四氮(PTZ)腹腔注射制备大鼠癫痫模型。随机将45只雄性SD大鼠分为空白对照组、清开灵治疗组、西药治疗组,按D ie-hl标准观察行为学表现及脑电图。结果:清开灵可延长癫痫发作潜伏时间(P<0.05),减少湿狗样抖动次数(P<0.05)和痫波发放频率。结论:清开灵对PTZ致痫大鼠有抗痫作用。

Objective To study the effects of Qingkailing on the behavior and electroencephalography of experimental epileptic rats. Methods 45 male SD rats were selected randomly into the groups of model, Qingkailing and sodium valproate. Pentetrazole was injected into abdominal cavity to establish model of epileptic rats which were applied to investigate the effects of anti-epilepsia drugs on the seizure severity and electroencephalography. Results Qingkailing can prolong the latency of epileptic seizure and epileptiform discharge, and reduce the seizure degree and frequency of discharge. Conclusion Qingkailing has an anti-epilepsy effect.