急性创伤患者血清促血小板生成素水平与血小板数关系的研究

Study on the relationship of serum thrombopoeitin level and platelet count in patient with acute trauma

目的探讨急性创伤患者血清促血小板生成素(TPO)水平与血小板数量的关系及其临床意义。方法应用定量夹心酶联免疫吸附试验(ELISA)和全自动血液分析仪分别对26例急性创伤患者进行TPO和血小板数检测,同时选择27名健康体检人员作为对照组。结果急性创伤患者血清TPO水平均显著高于正常,差异有非常显著性(P<0.001);急性创伤患者血小板数与正常组对比,差异无显著性(P>0.05);手术性创伤组TPO水平、血小板与非手术性创伤组比,差异均无显著性(P>0.05)。结论急性创伤时血清TPO水平与血小板数没有明显的相关性,血小板数目的改变不是导致TPO升高的主要因素,TPO升高可能参与组织急性损伤的保护和修复。

Objective To study the relationship of serum thrombopoeitin（TPO） level and peripheral blood platelet count in patient with acute trauma and its clinical significance. Methods TPO level and platelet count were detected in 26 patients with acute trauma by enzyme linked immunosorbent assay （ ELISA ） and automatic hemocytoanalyser. 27 healthy volunteers were assigned as control group. Results The statistical analysis showed that the serum TPO level in acute trauma group was higher than that in control group（ P 〈 0. 001 ）. The platelet count showed no difference between acute trauma group and control group（ P 〉 0.05 ）. The serum TPO level and the platelet count showed no difference between the operated group and the non operated group （ P 〉 0.05 ）. Conclusions The platelet count does significantly correlate with serum TPO level. The platelet count change is not the main reason that causes the increase of serum TPO level which participates possibly in the process of the tissue recovery and protection after acute trauma.