三种降压药治疗中重度高血压病的疗效观察

The therapeutic effects of amiodipine,lotensin and plendil on moderate or severe hypertension

目的比较氨氯地平、洛汀新与波依定对中重度原发性高血压患者的降压疗效。方法采用随机、单盲和交叉的方法,运用偶测血压监测。结果以偶测血压观察三种药物的降压效果,以及降低清晨平均血压的作用均无显著差异。氨氯地平、洛汀新降低白昼平均血压和全天24小时平均血压的幅度显著大于波依定。结论三种药物均能有效降低血压,但以氨氯地平更具优点:降低白昼及全天平均血压幅度优于波依定,而又没有洛汀新致咳嗽等不良反应。

Objective To compare the therapeutic effects of Amiodipine,lotensin and plendil on patients with moderate or severe hypertension. Methods Random, single-blinded and cross-over methods were adopted to assess the alterations of blood pressure monitored by occasional or dynamic measurements. Results There was no significant differences in the pressure-decreasing effects of these three drugs and in decreasing the mean blood pressure in the morning by occasional measurements.Amiodipine and lotensin decreased the mean blood pressure during daytime and during24hours to a significantly greater extent than plendil.Conclusion The three drugs can decrease blood pressure effectively, among which amiodipine is superior to other two in that it is more potent than plendil in decreasing pressure during daytime and all-around 24hours, and also it has no such adverse effects as coughing as lotensin does.