反应停在治疗血管发育不良所致消化道出血中的作用——附7例疗效观察

Novel Role of Thalidomide in Treatment of Recurrent Gastrointestinal Bleeding due to Angiodysplasias: An Analysis of 7 Cases

背景:血管发育不良所致的消化道出血常反复或持续发作,目前尚缺乏有效的治疗药物,而常规治疗又难以奏效,因此寻找一种安全有效的治疗方法已成为当前较为迫切的问题。目的:观察和研究反应停治疗血管发育不良所致的反复消化道出血患者的疗效。方法:予7例反复消化道出血的患者反应停100mg/d,疗程4个月,观察治疗前与治疗期间患者出血次数和血红蛋白含量的变化。结果:经4个月治疗患者的出血次数显著减少(P<0.05),血红蛋白含量显著上升,与治疗前4个月相比有显著性差异(P<0.01);临床症状亦明显改善(P<0.01)。结论:反应停治疗血管发育不良所致的消化道出血疗效显著。

Background： Obscure gastrointestinal bleeding secondary to angiodysplasia can be recurrent or persistent, and it has no specific drug therapy yet. Aims： To observe the therapeutic effect of thalidomide on recurrent gastrointestinal bleeding caused by gut angiodysplasia. Methods： Seven patients with gastrointestinal bleeding due to gut angiodysplasia were treated with thalidomide 100 mg daily for 4 months, and to compare the changes of bleeding frequency and hemoglobin levels before and during 4-month treatment with thalidomide. Results： The bleeding frequency of patients post-therapy was significantly less （P〈0.05）, and the hemoglobin level was significantly increased （P〈0.01） as well as the clinical symptoms remarkably improved （P〈0.01） after 4 months＇ treatment with thalidomide. Conclusions： Thalidomide is effective to cease the recurrent gastrointestinal bleeding in patients with gut angiodysplasia.