不同剂量米非斯酮用于紧急避孕的临床观察

Low doses of mifepristone for emergency contraception

目的比较米非斯酮10 m g和25 m g用于紧急避孕的有效性,副反应及可接受性。方法将无保护性交后72 h内的198例健康育龄妇女随机分为2组。Ⅰ组198例,口服米非斯酮10 m g;Ⅱ组100例,口服25 m g。于预期下次月经日期的第7天随访,了解避孕效果、副反应及月经的变化。结果2组紧急避孕的有效率分别为89.28%和89.04%,无统计学差异(P>0.05);各种副反应发生率较低,均在10%以内,2组相近;2组月经延迟5天以上者的比率分别为8.16%和12%,差异有显著性(P<0.05)。结论10 m g米非斯酮用于紧急避孕优于25 m g米非斯酮。

Objective To compare the efficacy,side effects and acceptability of mifepristone 10 mg and 25 mg for emergency contraception. Methods 198 cases of healthy women were recruited and allocated randomly in 2 groups. Group Ⅰ （n = 98） mifepristone 10 mg was given ;group Ⅱ （n=100） 20 rag. Follow-up visit was performed on the 7th day of the next expected period of menstruation in order to evaluate the contraceptive efficacy,side effects of mifepristone and the changes of menstruation. Results Contraceptive rates were 89.28% and 89.04% in group Ⅰ and Ⅱ . There was no statistical difference between the two groups （P〉0. 05）. The side effects were mild with incidence less than 10% in each group. The rates of delayed onset of next menstruation were 8.16% and 12% in group Ⅰ and Ⅱ respectively（P〈0. 05）. Conclusion Mifepristone 10 mg is better than mifepristone 25 mg for emergency contraception.