高血压病患者冠状动脉病变与血清尿酸水平的相关性

The correlation between coronary artery lesions of essential hypertension patients and their serum uric acid level

目的探讨高血压病患者血清尿酸水平与冠状动脉病变程度的相关性。方法对于经过冠状动脉造影的368例高血压病患者,测定血清尿酸及其它临床生化指标。根据冠状动脉造影结果分为冠心病组(n=240)和正常冠脉对照组(n=128)进行回顾性分析。结果冠心病组的血清尿酸水平(448.32± 115.12)μmol／L明显高于正常冠脉对照组(371.36±98.98)μmol／L(P＜0.001)；多因素逐步回归分析显示高血压病患者的冠状动脉狭窄程度与血清尿酸水平呈显著线性回归关系(P＜0.001)。结论高血压病患者的血清尿酸水平与冠状动脉狭窄程度密切相关。降低血清尿酸水平能否延缓或减轻冠脉病变程度,有待于进一步大规模前瞻性研究加以论证。

Objective To investigate the correlation between serum uric acid level and coronary artery lesions of essential hypertension patients.Methods The serum uric acid and other clinical biochemical parameters were measured in 367 essential hypertension patients who had undergone coronary angiography. According to the result of angiography,the patients were divided into coronary artery disease group（n=240）and normal coronary control group（n=128）.Data of two groups were analyzed retrospectively. Results The level of serum uric acid was significant higher in coronary artery disease group than that in the control group [（448.32 ±115.12 ） μmol/L vs （371.36 ±98.98）μmol/L,P〈0.001].Using stepwise regression analysis,a linear regression relationship was found between serum uric aeid,LDL,blood glucose two hours after meal and severity of comoary lesions in essential hypertension patients.Conclusion Serum uric acid level had a strong correlation with severity of coronary lesions in essential hypertension patients.Whether lowering of serum uric acid lead to alleviation of coronary lesions is remained to be demonstrated by further prospective research.