醇酸清漆挥发物对小鼠呼吸系统的影响

Effects of Volatile of Alkyd Varnish on Respiratory System in Mice

运用急性和慢性染毒方法,定期观察染毒期间和染毒后小鼠的行为变化,并观察染毒后呼吸器官的大体解剖和组织学变化.结果显示:与对照组相比,急性组小鼠在饮水量、食量和体质量等方面无显著变化,而慢性组小鼠的饮水量则有显著增加;急性组小鼠的鼻粘膜和气管粘膜受损,上皮细胞坏死脱落,肺泡隔变厚,血管中有部分红细胞渗入到肺泡隔内.慢性组小鼠鼻粘膜和气管出现轻度复层化或纤维化,肺部出现炎症灶.可见,醇酸清漆对小鼠的呼吸系统有一定伤害作用.

Action changes in both the period of exposure and convalescence were observed periodically using acute and chronic inhalation, and changes of anatomy and histology of respiratory organ were observed, too. The results showed that drinking, feeding and body weight were not changed obviously in the acute group, but the drinking in the chronic group was changed compared to the control group. In the acute group, the mucous membranes in nose and trachea were necrosis and broken off, the alveolar septum became thicker, and a part of erythrocytes in the blood vessels were permeated into the alveolar septa. In the chronic group, the mucous membranes were fibrosis or multistratum, and the inflammations could be seen in the lung. The results indicated that the volatile of alkyd varnish could destroy the respiratory system of mice in some extent.