恩丹西酮与氟哌利多在乳房肿瘤切除术后预防恶心呕吐疗效的比较

Preventive effect of ondansetron and droperidol on postoperative nausea and vomiting in patients underwent mastectomy

目的研究恩丹西酮对乳房肿瘤切除术后恶心、呕吐(PONV)的预防效果。方法选择60例在静脉复合麻醉下行乳房肿瘤切除的女性患者,随机分为Ⅰ组(恩丹西酮组,n=30),Ⅱ组(氟哌利多组,n=30)。Ⅰ组于手术前静脉推注恩丹西酮8mg,Ⅱ组静脉推注氟哌利多2.5mg。结果Ⅰ组术后24h恶心、呕吐例数远低于Ⅱ组。结论与氟哌利多相比,恩丹西酮能够有效地预防乳房肿瘤切除术后的恶心、呕吐。

Objective To study the preventive effect of ondansetron on postoperative nausea and vomiting （PONV）. Methods Sixty female patients underwent mastectomy under total intravenous ketamine anesthesia were investigated. The patients were divided into two groups randomly according to preventive use of antiemetic drags before anesthesia. Ondansetron 8rag was given in group Ⅰ （ n = 30 ） and droperidol 2.5mg in group Ⅱ （n = 30）. PONV was observed and recorded within 24 hours postoperative. Results The number of patients with PONV in group Ⅰ was much lower than group Ⅱ （ P 〈 0.01 ）. Conclusion Ondansetron has abetter preventive effect on PONV than droperidol.