伪人参皂苷GQ对异丙肾上腺素致大鼠急性心肌缺血的改善作用

Ameliorative effects of pseudoginsenoside GQ on isoproterenol-induced acute myocardial ischemia in rats

目的:探讨新化合物伪人参皂苷GQ(PGQ)对异丙肾上腺素致急性心肌缺血大鼠心电图改变的保护作用。方法:取Wistar大白鼠50只,随机分为生理盐水组、异搏定对照组及PGQ大、中、小3个剂量组, 每组10只。舌下静脉注射预防给药PGQ 3．0、6．0和12．0 mg·kg-1及异搏定0．2 mg·kg-1,然后静脉注射 2．0 mg·kg 1异丙肾上腺素,测量心电图(ECG)标Ⅱ、胸I(V1)和胸Ⅱ(V 2)ST段的变化。结果:标Ⅱ导联、V1导联、V 2导联PGQ小、中、大剂量组ST段在各时间点抬高不明显,ST段抬高幅度低于盐水组 (P<0．05,P<0．01,P<0．001)。结论:PGQ能明显降低异丙肾上腺素引起的ST段抬高,具有改善大鼠异丙肾上腺素致急性心肌缺血心电图改变的作用。

Objeotive To study the ameliorative effects of pseudoginsenoslde L/M （VbM） on electrocardiogram changes in rats with acute myocardial isehemia induced by isoproterenol （ISO）. Methods 50 Wistar rats were divided into five groups （n= 10） randomly. Group Ⅰ ： i.v. 0.9% sodium chloride water liquorl Group Ⅱ ： i.v. verapamil hydrochloride of 0.2 rag, kg^-1; Group Ⅲ.. i.v. 3.0 mg· kg^-1 of PGQ; Group Ⅳ i.v. 6.0 rag. kg^-1 of PGQ; Group Ⅴ ： i.v. 12.0 mg· kg^-1 of PGQ. Myocardial ischemia was induced by intravenous injection of ISO （2.0 mg · kg^-1）. ST-segment changes in the lead Ⅱ, precordial in lead Ⅴ and precordial in lead V2 were examined. Results In lead Ⅱ , lead precordial Ⅴ1 and lead precordial Ⅴ2 , ST-segment elevation of three PGQ groups were not obvious at every time point, the extents of ST segment elevation were lower than those in sodium chloride water liquor group （P^0.05, P〈0.01, P〈0.001）. Conclusion PGQ has the ameliorative effects on electrocardiogram changes in rats with ISO-induced acute myocardial ischemia.