摘要
目的:探讨新化合物伪人参皂苷GQ(PGQ)对异丙肾上腺素致急性心肌缺血大鼠心电图改变的保护作用。方法:取Wistar大白鼠50只,随机分为生理盐水组、异搏定对照组及PGQ大、中、小3个剂量组, 每组10只。舌下静脉注射预防给药PGQ 3.0、6.0和12.0 mg·kg-1及异搏定0.2 mg·kg-1,然后静脉注射 2.0 mg·kg 1异丙肾上腺素,测量心电图(ECG)标Ⅱ、胸I(V1)和胸Ⅱ(V 2)ST段的变化。结果:标Ⅱ导联、V1导联、V 2导联PGQ小、中、大剂量组ST段在各时间点抬高不明显,ST段抬高幅度低于盐水组 (P<0.05,P<0.01,P<0.001)。结论:PGQ能明显降低异丙肾上腺素引起的ST段抬高,具有改善大鼠异丙肾上腺素致急性心肌缺血心电图改变的作用。
Objeotive To study the ameliorative effects of pseudoginsenoslde L/M (VbM) on electrocardiogram changes in rats with acute myocardial isehemia induced by isoproterenol (ISO). Methods 50 Wistar rats were divided into five groups (n= 10) randomly. Group Ⅰ : i.v. 0.9% sodium chloride water liquorl Group Ⅱ : i.v. verapamil hydrochloride of 0.2 rag, kg^-1; Group Ⅲ.. i.v. 3.0 mg· kg^-1 of PGQ; Group Ⅳ i.v. 6.0 rag. kg^-1 of PGQ; Group Ⅴ : i.v. 12.0 mg· kg^-1 of PGQ. Myocardial ischemia was induced by intravenous injection of ISO (2.0 mg · kg^-1). ST-segment changes in the lead Ⅱ, precordial in lead Ⅴ and precordial in lead V2 were examined. Results In lead Ⅱ , lead precordial Ⅴ1 and lead precordial Ⅴ2 , ST-segment elevation of three PGQ groups were not obvious at every time point, the extents of ST segment elevation were lower than those in sodium chloride water liquor group (P^0.05, P〈0.01, P〈0.001). Conclusion PGQ has the ameliorative effects on electrocardiogram changes in rats with ISO-induced acute myocardial ischemia.
出处
《吉林大学学报(医学版)》
CAS
CSCD
北大核心
2006年第1期64-67,共4页
Journal of Jilin University:Medicine Edition
基金
吉林省科技厅科技发展重大项目资助课题(20011109-5)