4-间甲苯胺-3-吡啶磺酰胺的合成工艺改进

Improvement on Synthesis of 4-[(3-Methylphenyl)amino]-3-pyridinesulfonamide

以4-羟基吡啶-3-磺酸为原料,经氯化、氨解、缩合等3个步骤制备了4-间甲苯胺-3-吡啶磺酰胺,对氯化后处理、缩合反应及其精制进行了改进,总收率75%。

4-E （ 3-Methylphenyl ） amino]-3-pyridinesulfonamide was synthesized by chlorination, ammonolysis,condensation and purification, using 4-hydroxy-3-pyridinesulfuric acid as the raw material, The process of chlorization,condensation and purification were improved. The total yield was 75%.