新生儿缺氧缺血性脑病血小板参数的动态变化

The dynamic changes of platelet parameter in neonatal hypoxic-ischemic encephalopathy

目的探讨新生儿缺氧缺血性脑病（HIE）血小板参数的动态变化及临床意义。方法对2001年1月～2004年12月被确诊为新生儿HIE的72例患儿的血小板参数即血小板计数（plt）、平均血小板容积（MPV）和血小板分布宽度（PDW）进行动态观察，50例正常的足月儿作为对照组，两者进行比较。结果①HIE患儿急性期PLT较对照组明屁降低（P〈0．01），MPV和PDW则较对照组明显增高（P〈0．05），两组恢复期PLT、MPV和PDW无明显差异（P〉0．05）。②HIE患儿PLT随病情加重而下降（P〈0．05或P〈0．01），MPV、PDW则随病情加重而增高（P〈0．05，P〈0．01）。结论动态观察HIE患儿血小板参数，可作为判断HIE病情严重程度的指标。

Objective To study the dynamic changes of platelet parameter in neonatal hypoxic - ischemic encephalopathy （HIE） and the clinical significance. Methods From January 2001 to December 2004,72 cases of neonatal HIE were final diagnosed, whose platelet count （ pit）, mean platelet volume （MPV） and platelet distribution width （PDW） were dynamic observed. It was compared with 50 cases of normal infants. Results ①Plt in acute period of HIE was significantly lower than that of normal infants （ P 〈 0. 01 ）, and MPV and PDW were significantly higher than that of normal infants （ P 〈 0. 05 ）. There were no significant differences in two groups＇pit, MPV and PDW in convalescences（ P 〉 0. 05 ）. ②The pit in the HIE infants were decreased （P 〈 0.05, P 〈0.01）and the MPV,PDW were increased（ P 〈0.05 or P 〈0.01）by the degree of severity. Conclusion Observing HIE infant＇s platelet parameter dynamically can be regarded as the index of judging HIE＇s condition severity.