摘要
目的观察经去多糖处理后加味四妙方的抗炎、镇痛作用以及对痛风性关节炎的影响,筛选加味四妙方抗痛风的有效部位群。方法采用醋酸刺激致小鼠扭体反应试验、二甲苯致小鼠耳肿胀试验、尿酸钠结晶致大鼠足肿胀试验。结果全方经去多糖工艺处理后,仍保持显著的抗炎、镇痛作用,且有量效关系。结论去多糖处理不影响全方的抗炎、镇痛作用。
Objective To observe the anti - inflammation and analgesic action and anti - urarthritis effect of modified Simiao prescription with polysaccharide removal and thus to screen the effective anti - gout components from modified Simiao prescription. Methods Mouse acetic - acid - induced twisting experiment, mouse xylene - induced auricular swelling experiment, and rat sodium - urate - induced pedal swelling experiment were carried out in this study. Results After the removal of polysaccharides, modified Simiao prescription still kept obvious anti - inflammation and analgesic action and in a dose - effect manner. Conclusion Polysaccharides removal has no influence on the anti - inflammation and analgesic action of modified Simiao prescription.
出处
《中药新药与临床药理》
CAS
CSCD
2006年第1期7-9,共3页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
江苏省自然科学基金资助项目(BK2002033)。
关键词
加味四妙方
多糖
痛风
抗炎
镇痛
Modified Simiaoprescription
Polysaccharide
Gout
Anti -inflammation
Analgesic action
