噁唑酮金属配合物的研制

Synthesis and studies of metal comlexs of oxazolidinones

目的研制高效低毒的中枢种经系统调节剂，探索 唑酮金属配合物的合成方法．方法选择以扁桃酸为原料，采用苯回流带水进行酯化，再与硝酸胍缩合，然后与用氢氧化钠溶于乙醇中的金属盐配合的合成路线．结果经多步反应合成３种 唑酮的金属配合物，以待进行临床药理鉴定．结论此合成路线方法简便且收率高，为合成唑酮类化合物提供了行之有效的方法。

Objective To research the synthsis of metal complexs of 2-imino-5-phenyl-4-oxazolidinone and to study more efficient and lower poisonous central nervous system stimulants.Mcthods Choosing mandelic acid as the starting material,the esterifying reaction was complished by refluxing benzene to remove water. The oxazolidinone was prep by combining ethyl mandelate with guanidine nitrate. The metal complexs was chelated with Mg2+,Cu2+. Fe3+by solubilizing in EtcH with NaOH. Results Three metal complexs have been systhesized from mandelic acid through three steps, being expected clinical pharmaceutical evalution. Conclusion This synthetic route is short with a high yield, and provid a method to synthesis of oxazolidinones.