卡维地洛对冠心病伴焦虑患者的疗效观察

Efficacy of Carvedilol in Coronary Heart Disease with Anxiety

目的观察卡维地洛对冠心病伴焦虑患者的疗效方法:用卡维地洛治疗冠心病伴有焦虑障碍(A组)30例,与不伴有焦虑障碍患者(B组)30例各8周,对两组治疗前后活动平板的运动耐量指标变化进行对照。结果:两组在治疗后的运动总步行时间,运动至心绞痛出现时间和运动到ST段压低达0.1mv,所需时间均较治疗前有明显延长(P<0.05),但A组的效果比B组更显著(P<0.05),尤其是病人症状出现的时间(P<0.001),差别更大,A组的BAI评分改变更明显。结论:卡维地洛治疗冠心病伴有焦虑障碍的患者效果更显著。

Objective To evaluate whether Carvedilol is more beneficial in Coronary Heart Disease（CHD） with anxiety than without anxiety. Method CHD patients with anxiety （group A, n=30） and without anxiety（group B, n=30） were received Carvedilol for 8 weeks, the tolerance of exercise stress test was compared between these two group before and after the trial. Result All cases showed a significant improvement in total exercise walking time, time to 0.1mV ST-segment depression （p〈0.05） after the combination therapy with carvedilol, which was more significant in group A than in group B（p〈0.05）, the time to onset of anginal was distinguish prolong （p〈0.001）. The Beck Anxiety Inventory （BAD in group A were changed more significant than group B （p〈0.05）. Conclusion In CHD with anxiety therapy with carvedilol get more significant effect than those without anxiety.