雷帕霉素洗脱支架对介入术后血管内皮再生的影响

Effect on endothelium regeneration after implantati on of Cypher^(TM) stent

目的:研究雷帕霉素洗脱支架(CypherTM)对血管内皮再生的影响。方法:杂种犬3只,经麻醉后行血管造影,选择动脉血管直径为2·25mm的直血管段在远端及近端分别置入直径为2·25mm的CypherTM支架及Bxsonic支架。术后仍继续给予抗血小板治疗,饲养30d行再次血管造影后取标本行扫描电镜检查。结果:术后30d血管造影CypherTM支架及Bxsonic支架均无管腔丢失。扫描电镜显示CypherTM支架内皮覆盖不完整,有一定的血小板黏附、聚集。Bxsonic支架内皮覆盖完整,未见血小板黏附聚集。结论:CypherTM支架内皮再生较裸金属支架缓慢,有一定的血小板激活。置入CypherTM支架的患者应进行更为严格的抗血小板治疗。

Objective： To evaluate the effect on endothelium regeneration and platelet activation after implantation of Cypher^TM Stent. Method：3 mongrel dogs were implanted Cypher^TM stent and Bx sonic stent in the same artery.30 d after implantation of stems, the target vessel were ablated after angiography and observed by scanning electron microscope. Result：Target vessel of Cypher^TM stent were covered with endothelium partly. Platelet activation were observed .Target vessel of Bx sonic stent were entirely covered with endothelium. Platelet activation weren＇t observed. Conclusion： Endothelium regeneration after impantation of Cypher^TM stent were much slower than bare metallic stent. Intensive anti-platelet therapy should be considered after implantation of Cypher^TM .