恩诺沙星微胶囊的制备及其抗紫外、热稳定性的研究

Preparation of microencapsulation of enrofloxacin and analysis of anti-ultraviolet character & thermal stability

采用冷冻干燥法,分别以羧甲基纤维素和淀粉为壁材,制备恩诺沙星微胶囊制剂。抗紫外和热稳定性试验表明:以羧甲基纤维素和淀粉为壁材的恩诺沙星微胶囊均有抗紫外和热稳定性能。其中,羧甲基纤维素与恩诺沙星、淀粉与恩诺沙星包埋质量比为1∶1、1∶2时,微胶囊表现出显著的抗紫外作用(P<0.05);羧甲基纤维素与恩诺沙星、淀粉与恩诺沙星包埋质量比为2∶1、1∶1、1∶2时,微胶囊表现出极显著的热稳定性(P<0.01)。羧甲基纤维素的抗紫外和热稳定性均优于淀粉,但差异不显著。

By the freezing-drier, the microencapsulation of enrofloxacin enveloped by cellulose CM and starch were prepared. The anti-ultraviolet character and thermal stability of the microencapsulation were analyzed. The results showed that： the microencapsulation of enrofloxacin enveloped by both cellulose CM and starch had the potential to avoid being decomposed under the ultraviolet rays and the high temperature. Furthermore, the microencapsulation of enrofloxacin with cellulose CM and enrofloxacin in the mass ratio of 1 ： 1 and 1：2 showed us the distinct diversity in anti-uhraviolet characters（ P 〈 0.05） while those with cellulose CM and starch in the ratio of 2 ： 1, 1 ： 1 and 1：2 showed us the particularly distinct diversity in the thermal stability（ P 〈 0. 01 ）. The anti-ultraviolet ability and the thermal stability of cellulose CM are superior to starch, in which the diversity is not distinctive.