母体血清IgG亚型含量与新生儿溶血病的关联

The Relationship between the Concentration of IgG Isoforms in Maternal Serum and Heamolytic Disease of Newborn

目的探讨母体血清IgG抗体亚型含量在新生儿溶血病发病中的作用。方法采用常规ELISA法对64例HDN患儿母亲、48例患儿及23例正常对照样本血清中IgG各亚型进行定量分析。结果患儿母亲血清中IgG1、IgG3和IgG4的含量明显高于正常对照组(P<0.01),与患儿的差异无显著性(P>0.05)。患儿血清中IgG各亚型构成与母体的不完全一致。结论母体血清中IgG1和IgG3的含量,尤其是IgG1的含量与ABO血型系统的新生儿溶血病发病密切相关。

Objective To search the role of IgG isoforms in the pathogenesis of heamolytic disease of newborn. Methods ELISA was used to determine the concentration of IgG isoforms in maternal serums. Results The concentration of IgGl,IgG2 and IgG3 in ill-infant mother＇s serum were higher than that in controls （P〈0.01） while there was no difference from infant＇s（P〈0. 05）. The constituent ratio of IgG isoforms in mothers and infants was not consistent. Conclusion It suggested that the concentrations of IgG1 and IgG3 in mother＇s serum ,especially IgG3 is important in pathogenesis of heamolytic disease of newborn caused by ABO blood type.