2型糖尿病患者糖化血红蛋白、空腹血糖与视网膜病变关系的研究

The relationships among glycated haemoglobin, fasting blood glucose and diabetic retinopathy in patients with type 2 diabetes mellitus

目的探讨糖化血红蛋白(HbA1c)、空腹血糖(FBG)与2型糖尿病性视网膜病变(DR)的关系。方法对156例 2型糖尿病(DM)中伴有DR患者(DR组)71例、未伴有DR患者(NDR组)85例进行HbA1c、FBG检测,分析HbA1c、FBG 与DR的关系。结果 DR组的HbA1c水平显著高于NDR组(P<0．01),且HbA1c水平越高,DR发生率也增加(P<0． 05)。但两组FBG水平比较差异无显著性(P>0．05)。结论 HbA1c水平对判断DR的病情变化和预后有参考价值,可作为监测DM患者DR发生、发展的重要指标。

Objective To evaluate the relationships among glycated haemoglobin （HbA1c）, fasting blood glucose （FBG） and diabetic retinopathy （DR） in type 2 diabetes mellitus （DM）. Methods The concentrations of HbA1c and FBG in one hundred and fifty - six patients with type 2 DM had been measured, seventy - one of them associated with DR （group DR） and eighty- five of them associated without DR （group NDR）. The relationships among HbA1c, FBG and DR were analyzed. Results The HbA1c levels in group DR were higher than those in group NDR, there were statistically significant differences （ P 〈0.01）; moreover, the higher the levels of HbA1c were, the higher the incidence of DR was （ P 〈0.05）. In comparison of the FBG levels in the two groups, there were no statistically significant differences （ P 〉0.05）. Conclusion HbA1c level may be one of the effective markers for predicting the incidence of DR and for monitoring DR pathogenosis in patients with DM.