2种缝合方法的动物实验对比研究

Animal experiment contrast study of two kinds of suturing method

目的探讨2种缝合方法对切口愈合的影响。方法采用拆线缝法和普通逐层缝合方法同时作用于实验兔腹部,从病理上观察异物反应、成纤维细胞数量、炎症细胞浸润及胶原增生4方面情况。结果采用拆线缝法的实验组在异物反应、炎症细胞浸润及胶原增生方面于拆线后较普通缝合法有明显改善。结论拆线缝法有利于组织修复和伤口的重建,能减少瘢痕的过度形成并减轻了瘢痕的挛缩情况,比普通逐层缝合更有利于创伤的修复。

Objective It is to discuss the influence of two kinds of suturing method on wound healing. Methods Tie removal suture and normal suture by layer upon layer were utilized on closure of abdominal surgical incisions in rabbits at the same time, Response of foreign body, numbers of fibroblasts, infiltration of inflammation cells and collagen hypertrophy were pathologically observed. Results Response of foreign body, infiltration of inflammation cells and collagen hypertrophy in experiment group were obviously ameliorated than those in control group after sutures out. Conclusion Tie removal suture is benefited for tissue repair and wound reconstruction by reducing excessive scar formation to ameliorate scar constriction, and it is better for wound repair than the normal suture by layer upon layer.