冠心Ⅱ号对健康男性肠系膜下动脉血流动力学的影响

Effect of Coronary Heart No 2 on the Hemodynamics of Inferior Mesentery Artery in Healthy Male Volunteers

目的:探讨临床常用剂量冠心Ⅱ号喷雾干燥剂对健康男性肠系膜下动脉(inferior mesenteric artery,IMA)血流动力学的影响。方法:按生药量0.75g/kg体重给9例男性健康自愿者服用冠心Ⅱ号喷雾干燥剂前后,使用彩色多谱勒超声检查其肠系膜下动脉,参数测量指标有舒张期最大血流速度(Vmax)、舒张期最小血流速度(Vmin)和平均血流速度(Vmean)、肠系膜下动脉血管内径和血流量。结果服药前后比较Vmax和Vmin没有统计学差异(P>0.05),但Vmean、直径和血流量有显著差别(P<0.05)。结论:常规剂量冠心Ⅱ号喷雾干燥剂对健康男性IMA血流动力学有明显影响。

Objective：To explore the effect of normal clinical dose spray-dried Coronary heart No 2 powder on the hemodynamics of inferior mesentery artery （IMA） in healthy male volunteers. Method： Hemodynamic parameters of the IMA were obtained through Doppler sonography before and after administration of spray-dried Coronary heart No 2 powder （dosage of 0.75g/kg crude formulation） in 9 healthy male subjects. Results：Significant difference of Doppler parameters including vessel inner diameters, the mean velocity and blood flow volumes in IMA were found before and after administnaion（ P 〈 0.05） while the maximum and minimum velocity had no statistic significance. Conclusion： Normal clinical dose spray-dried Coronary heart No 2 powder influence the hemodynamic of IMA in healthy male volunteers.