局部糖皮质激素治疗慢性非变应性鼻炎的疗效分析

Clinical observation on intranasal budesonide in chronic nonallergic rhinitis

目的:探讨局部应用糖皮质激素鼻喷雾剂布地奈德(Budesonide)治疗慢性非变应性鼻炎(NAR)的临床效果。方法:对42例慢性NAR患者,应用鼻腔内鼻喷雾剂布地奈德局部治疗8周,每次每侧鼻孔内喷入64μg,2个鼻孔共128μg,早晚各1次。并做症状及体征分级记分。结果:治疗后各项症状及体征评分均有下降,其中治疗后1周与治疗前比较,流涕、鼻痒、头晕、头痛等症状差异有统计学意义(P<0.05);治疗后8周与治疗前比较,鼻塞、流涕、鼻痒、闭塞性鼻音、头晕、头痛等症状差异有统计学意义(P<0.05)。结论:局部应用布地奈德可不同程度地改善慢性NAR患者的临床症状。

Objective： An open randomized comparative study was conducted in order to observe the efficacy and safety about intranasal Budesonide in the treatment of chronic nonallergic rhinitis. Method： Forty-two patients with chronic nonallergic rhinitis were treated with Budesonide aqueous nasal spray （256 μg once daily intranasally） for 8 weeks. All the patients were asked for return at week 1 and week 8. Efficacy was evaluated by measurement of nasal symptom scores and sign scores at week 0, week 1 and week 8 Result：All the parameters measured were improved after treatment. Specifically, from week 0 to week 1, the scores of nasal secretions, itchy feeling of the nose and headache showed a significant decrease than that before treatment. From week 0 to week 8, the scores of nasal obstruction, nasal secretions, itchy feeling of the nose, closed rhinolalia and headache were significantly less than the record at week 0. However, there were not significant influences on the smell disturbances, dryness of the throat. No serious adverse events were reported in the study. Conclusion： Intranasal Budesonide is effective and safe in alleviating the symptoms of chronic nonallergic rhinitis.