GC测定感冒康喷雾剂中桉油精、樟脑、薄荷脑和龙脑的含量

Determination of eucalyptol, camphor, menthol and borneol in Ganmaokang Spray by GC

目的：建立中药复方制剂中桉油精、樟脑、薄荷脑和龙脑含量测定的方法。方法：采用毛细管气相色谱法，弹性石英毛细管柱（30m×0．53mm×1．2μm）EC—WAX；萘为内标。结果：桉油精、樟脑、薄荷脑和龙脑线性范围分别为0．38448～0．89712mg／mL，0．2406—0．5614mg／mL。0．36756—0．8576mg／mL，0．1356—0．3164mg／mL；平均加样回收率分别为98．4％，98．2％，98．5％，98．2％（n=5）。结论：该方法快速、方便，分离度好，其他成分无干扰，适用于复方制剂中4种成分的同时测定。

AIM： To establish a method of determining eucalyptol, camphor, menthol and borneol in Ganmaokang Spray. METHODS ： GC was conducted on a EC-WAX column （30 m × 0.53 mm × 1.2 μm） and naphthalene was adopted as internal standard. RESULTS： Eucalyptol, camphor, menthol and borneol respectively showed a good linear relationship in the following ranges of concentration： 0. 384 48-0. 987 12 mg/mL, 0. 240 6 0. 561 4 mg/mL,0. 367 56-0.857 6 mg/mL and 0. 135 6-0.316 4 mg/mL. The average recoveries were obtained as 98.4%, 98.2% , 98.5% and 98.2% （ n = 5）. CONCLUSION： The method is simple, sensitive, accurate and suitable for the determination of four constituents in Ganmaokang Spray.