期刊文献+

两种血液吸附器血透对尿毒症患者血清β_2-MG和IL-6的影响 被引量:1

The impact of two blood absorber hemodialysis on the level of β_2-MG and IL-6 in uremia patients.
下载PDF
导出
摘要 目的探讨中性树脂HA-330型和活性炭YTS-200型血液吸附器串连低通量血液透析对尿毒症患者血清β2-MG和IL-6的影响。方法30例维持性血透病人,交叉对照设计,清洗期1周;以常规间隙性低通量透析(IHD)为基础治疗,HA-330和YTS-200两种不同的血液吸附器为干预手段与F6低通量血液透析器串连,检测治疗前后血常规、肝肾功能、电解质、血清β2微球蛋白(β2-MG)、白介素6(IL-6)水平,计算治疗后β2-MG、IL-6的下降率,比较三种治疗对血清β2-MG、IL-6、血小板的影响。结果正常对照血清IL-6为106·467±89·585pg/ml,β2-MG为81·579±25·417nmol/L;30例尿毒症病人,去除血液浓缩影响,IHD、IHD+HA-330、IHD+YTS-200三种治疗IL-6/HCT的下降率分别为8·1±40·2、-15·1±110·7、-10·8±96·8,三者间差异无显著性(P>0·05);IHD、IHD+HA-330、IHD+YTS-200三种治疗β2-MG/HCT的下降率分别为-9·5±60·8、-16·4±43·1、-6·6±26·7,三者间差异无显著性(P>0·05);IHD治疗前后PLT/HCT为77·75±31·60、80·59±34·55,差异无显著性(P>0·05);IHD+HA-330治疗前后PLT/HCT分别为82·21±39·22、68·94±33·55,治疗后显著降低(P<0·05),IHD+YTS-200治疗前后PLT/HCT为70·64±27·46、53·56±20·80,治疗后显著降低(P<0·05)。结论IHD、IHD+HA-330、IHD+YTS-200三种治疗后尿毒症患者血清β2-MG、IL-6无降低;HA-330、Aier-200引起PLT显著降低,提示HA-330和YTS-200两种血液吸附器生物相容性欠佳。 Objective To study the influence of synthetic polymers type HA - 330 and actived carbon type YTS - 200 hemoadsorption devices conjugated with low flux bemodialysis on uremic patients' serum β2- MG and IL- 6. Methods Crossover design was made and 30 cases maintenance hemodialysis uremia patients were treated with conventional intermittent low - flux hemodialysis (IHD), one week as wash - out period, HA - 330 and YTS - 200 hemoadsortion devices conjugated with low flux F6 dialyzer as interferences, blood routine, liver and kidney function index, eletrieytes, serum β2- MG and IL - 6 were measured before and after treatment. The β2- MG and IL- 6 reduction rate of the three kinds therapies and their influences on blood platelet were compared. Results Normal values of IL- 6 andβ2- MG were 106.467±89.585pg/ml and 81.579±25.417nmol/L. The reduction rate of serum IL - 6/HCT in the 30 cases uremia patients after treated with IHD,IHD + HA - 330,IHD + YTS - 200 were 8.1±40.2 , - 15.1±110.7 and - 10.8±96.8,respectively. No significant difference was observed (P 〉 0.05); the reduction rate of IHD,IHD + HA - 330,IHD + YTS - 200 to serum β2- MG/HCT was - 9.5±60.8, - 16.4±43.1, - 6.6±26.7 respectively, no significant difference ( P 〉 0.05) ; the levels of PLT and HCT were 77.75±31.60 and 80.59±34.55 before and after IHD therapy, no significant difference was noticed ( P 〉 0.05) ; the levels of blood PLT and HCT before and after IHD + HA - 330 therapy were 82. 21±39.22 and 68.94±33.55 respectively, significantly decreased ( P 〈 0.05). the levels of blood PLT and HCT before and after IHD + YTS - 200 were 70.64±27.46 and 53.56 ±20.80, significantly decreased ( P 〈 0.05 ). Conclusion After IHD, IHD + HA - 330, IHD + YTS - 200 therapies, the levels of serum β2- MG and IL - 6 did not decrease. The level of blood PLT decreased significantly after use of HA - 330 and Aier- 200, showing a poor biocompatibility in the use of HA - 330 amd YTS - 200 with.
出处 《中国热带医学》 CAS 2006年第1期9-12,共4页 China Tropical Medicine
基金 2004海南省人民医院出国留学回国人员研究基金
关键词 尿毒症 血液透析 血液吸附 β2微球蛋白(β2-MG) 白介素6(IL-6) Uremia Hemodialysis Hemoadsorption β2- MG IL - 6
  • 相关文献

参考文献14

  • 1Mikhalovsky SV,Emerging technologies in extracorporeal treatment:focus on adsorption[J].Perfusion,2003,18(7):47-45.
  • 2James F,et al.Removal of Middle Molecules with Sorbents[J].Artif Cells Blood Substit Immobil Biotechnol,2002,30(5-6):547-554.
  • 3Winchester JF,et al:The next step from high-flux dialysis:application of sorbent technology[J].Blood Purif,2002,20(1):81-86.
  • 4Gejyo F,Kawaguchi Y,Hara S,et al.Arresting dialysis-related amyloidosis:a prospective multicenter controlled trial of direct hemoperfusion with a beta2-microglobulin adsorption column[J].Artif Organs,2004 ,28(4):371-380.
  • 5Clark WR,et al.Middle molecules and small-molecular-weight protiens in ESRD:Properties and strategies for their removal[J].Adv Ren Replace Ther,2003,10(4):270-278.
  • 6Ronco C,Brendolan A,Winchester JF,Et al.First clinic experience with an adjunctive hemoperfusion devices design specifically to remove beta 2-microglobulins in hemodialysis[J].Contrib Nephrol,2001,133:166-173.
  • 7Morena MD,Guo D,Balakirishna VS,et al.Effect of a novel adsorbent on cytoking responsiveness to uremic plasma[J].Kidney Int,2003,63(3):1150-1154.
  • 8龚德华,季大玺,徐斌,王金泉,刘云,黎磊石.高通量透析器的临床应用[J].肾脏病与透析肾移植杂志,2002,11(5):411-414. 被引量:40
  • 9叶朝阳,徐涛,毛志国,张斌,陈静,梅长林.高通量血液透析对慢性肾衰患者甲状旁腺素和β_2微球蛋白的清除作用[J].第二军医大学学报,2003,24(3):318-320. 被引量:31
  • 10姚刚,方奕,武晓春,曾志立.高通量血液透析对长期透析患者血清β_2-MG浓度的影响及其临床意义[J].中国血液净化,2004,3(3):144-146. 被引量:23

二级参考文献17

  • 1龚德华,季大玺,谢红浪.高通量透析器复用的研究[J].医学研究生学报,2000,13(5):307-310. 被引量:26
  • 2[3]Luster MI, Germolec DR, Yoshida T, et al. Endotoxin induced cytokine gene expression and excretion in the liver. Hepatology, 1994,19:480
  • 3[4]Onji M, Horiike N, Ohta Y. Patterns and pathobiology of hepatic necrosis in chronic viral hepatitis. Gastroenterologia Japonica, 1993,28:26
  • 4[5]Sanchez JA, Perez JL. Cytokines clearence during veno- venous hemofiltration in the trauma patients. Am J Kid Dis, 1997,30:438
  • 5Falkenhagen G,Brown GS.Possibilities of selective and unselective absorbent development in blood purification[A].In:Klinkmann H,Smeby LC.Contributions t o Nephrol.Vol.78,Terminal renal failure:Therapeutic problems,possibilities and potentials[M].Karger:Basel-Munchen,1990.142-156.
  • 6Eknooyan G,Beck GJ,Cheung AK,et al.Effect of dialysis dose and membrane flux in maintenance hemodialysis[J].N Engl J Med,2002,347(25):2010 -2019.
  • 7刘平.透析膜的生物相容性[A].见:王海燕主编.肾脏病学[M].第2版. 北京:人民卫生出版社,1997.1469-1475.
  • 8Barth RH.Pros an d cons of short,high efficiency,and high-flux dialysis[A].In:Winchester JF,Jacobs C,Kjellstrand CM ed.Replacement of renal function by dialysis[M].4 th ed.Dordrecht:Kluwer Academic Publishers,1996.418-453.
  • 9Almaden Y,Canalejo A,Ballesteros E,et al.Effect of high extracellular phosphate concentration on arachidonic acid production by parathyroid tissue in vitro[J].J Am Soc Nephrol,2000,11(8):1712-1716.
  • 10Movilli E,Zani R,Carli O,et al.Direct effect of the correction of acidosis on plasma parathyroid hormone concentrations,calcium and phosphate in hemodialysis patients:a prospective study[J].Nephron,2001,87(3):257-259.

共引文献120

同被引文献5

引证文献1

二级引证文献5

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部