狼疮肾炎早期诊断的相关因素回归分析

Regression analysis of factors associated with early diagnosis of lupus nephritis.

目的探讨狼疮性肾炎(LN)病变早期诊断的相关因素。方法对53例LN患者进行回顾性分析,并与同期住院的61例无肾炎病变的SLE患者对照。结果LN患者占同期住院患者的46·5%。与无肾炎病变的SLE患者作对照,其发病年龄明显小于对照组(P<0·001),两组性别和病程方面差异无显著性(P>0·05)。实验室指标对比显示,抗dsDNA抗体、抗sm抗体、抗心磷脂抗体(aCL)和抗中性粒细胞胞质抗体(ANCA)在LN组有较高的阳性率,与对照组相比差异有显著性(P<0·05)。结论发病年龄小,抗dsDNA抗体、抗Sm抗体、aCL和ANCA阳性是SLE易并发肾炎的危险因素。

Objective To explore the factors associated with the development of lupus nephritis （LN） in systemic lupus erythematosus patients. Methods A retrospective study of 53 LN patients and 61 SLE patients without nephritis were randomly selected as controls. Standard methods were used for laboratory testing. Results LN Patients were significantly younger than the controls at the ages of onset （ P 〈 0. 001 ）. There were no differences in sex distribution and disease duration between the two groups. The laboratory tests showed that the positive rate of anti - dsDNA, anti - Sin, anti - cardiolipin （aCL） and antineutrophil cytoplasmic autoantibodies （ANCA） were higher in the group with nephritis than in control group （ P 〈 0.05）. Conclusion Young patients positive for anti - dsDNA, anti - Sm, aCL and ANCA appear to have a higher risk of renal involvement. These patients should be carefully monitored for the development of IN.