乳腺癌血清E-选择素与糖类抗原72-4联合检测临床意义

Clinical significance of combined detection the serum levels of E-selectin and CA72-4 in breast cancer

目的:探讨血清E-选择素、糖类抗原72-4(CA72-4)与乳腺癌浸润、转移及术后复发的关系,分析二者联合检测对乳腺癌新辅助化疗效果的评估作用。方法:采用ELISA测定93例乳腺癌患者血清E-选择素及CA72-4值,与健康正常人20例作对照。结果:乳腺癌68例手术病例中血清E-选择素、CA72-4值显著高于对照组(P<0.01);乳腺癌术后血清E-选择素、CA72-4值低于术前(P<0.01)。术后复发组血清CA72-4值高于术后无复发组(P<0.05)。淋巴结转移组血清E-选择素值高于淋巴结未转移组(P<0.05)而血清CA72-4值变化无统计学意义(P>0.05)。25例患者先行新辅助化疗,部分缓解(PR)13例,完全缓解(CR)4例,无变化(NC)8例,进展(PD)0例,缓解组血清E-选择素及CA72-4值化疗后显著低于化疗前(P<0.01)而未缓解组化疗前、后无统计学意义(P>0.05)。结论:联合检测E-选择素及CA72-4可用于乳腺癌术后复发监控、评估化疗效果、筛选高危患者以利于早期综合治疗。

Objective ：To find out the connection of serum E - selectin and CA72 - 4 with metastasis, recurrence and infiltration of breast cancer. Methods：93 women who underwent surgery for breast cancer were studied prospectively. Venous blood samples were collected before and after operation,and before and after chemotherapy. The serum of E - selectin and CA72 -4 were measured by using ELISA and the clinical values were assessed. Two control groups consisted of 20 healthy women. Results：68 patients underwent operation is prior to chemotherapy. The levels of E - selectin and CA72 -4 from the 68 patients wre signiticantly higher（ P 〈 0.01 ） preoperatively and postaperatively comparved with the control group,The serum CA72 -4 levels were higher in women with tumor recurrence and lymph node metastasis （ P 〈 0.01 ） but when it came to metastasis group, the apparent changes had taken place on E -selectin （P 〈 0.05 ）. Of the 93 patients,25underwent neoadjuvant chemotherapy prior to operation. In the clinical response group, the levels of E - selectin and CA72 - 4 in patients after chemotherapy were lower than those before chemotherapy（ P 〈 0.01 ）. Conclusion ：The comkined detection of serum E - selectim and CA72 -4 levels may be applied to monitoring the post -operative recurrence ,evaluating the effect of chemotherapy and selecting individualized treatment of breast cancer.