肝脏抗菌多肽在铁代谢中的调节作用

A Putative Iron-regulatory Hormone Hepcidin

人体存在着严格的铁代谢调节机制,以确保体内铁始终处于正常生理水平.这种机体铁稳态关键依赖于小肠铁吸收和机体铁需要之间的平衡.研究显示肝脏抗菌多肽很可能是一种控制小肠铁吸收及调节体内铁稳态的关键物质,是一种极为重要的铁调节激素.肝脏抗菌多肽可以反映体内铁的储存状态,在铁积聚时肝脏抗菌多肽表达增加,使小肠铁吸收减少,巨噬细胞铁储存增多;铁缺乏时肝脏抗菌多肽表达减少,使小肠铁吸收增加,巨噬细胞释放铁增加.

The normal physical level metabolism. This iron homeostasis is de of iron is ensured by the rigid reg nal ulation mechanism ol iron iron absorbing and iron demanding in the body. The study showed that hepcidin may be a key factor to control intestinal iron absorbing and regulate iron homeostasis in body, and may be an important hormone of iron metabolism regulating. The iron storage state could be reflected by hepcidin, when iron was accumulated hepcidin expression was increased which then could make intestinal iron absorbing and iron storage in macrophag decreased, but when iron was deficient hepcidin expression was decreased which then could make intestinal iron absorbing and iron storage in macrophage increased.