摘要
蛋白酶活性受体PARs是一种G蛋白耦联受体,目前这个家族中研究得比较清楚的主要是两个成员:蛋白酶活性受体-1(PAR-1)和蛋白酶活性受体-2(PAR-2),这两类受体广泛分布在多类组织和细胞中,包括内皮细胞,T淋巴细胞和平滑肌细胞等等。由凝血酶和类胰蛋白酶这两种丝氨酸蛋白酶类分别激活PAR-1和PAR-2所介导的信号转导机制所引起的一系列反应在哮喘的发病机制中起着十分重要的作用,并且有望能为哮喘的治疗提供新的方向。
Proteinase-activated receptors（PARs） are belong to the category of G protein-coupled receptors. By far, there are two relatively clear defined members in this great family, namely, Proteinase-activated receptor-1 （PAR- 1 ）and Proteinase-aetivated receptor-2（ PAR-2）. Two receptors are widely seen in various tissues and cells, such as endothelial cells, T lymphocytes, and smooth muscle eells, etc. A series of reactions caused by signal transmitting mechanism mediated by the activations of PAR-1 and PAR-2 which they are aetivated by thrombin and tryptase, respectively, play a pivotal role in pathogenic mechanism of asthma, It also have the potential of providing a new method for asthma.
出处
《医学综述》
2006年第1期8-10,共3页
Medical Recapitulate
