期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

基质金属蛋白酶与脑缺血研究进展 被引量：4

Progress in the Research on Matrix Metallproteinase and Cerebral Ischemia
下载PDF
导出
摘要 基质金属蛋白酶与缺血性脑血管病的发生,脑缺血后脑损伤及再灌注关系密切,基质金属蛋白酶抑制剂可能成为防治缺血性脑血管病的新靶点。 There is a close relationship between matrix metalloproteinase and the development of cerebral ischemia, as well as the following cerebral damage and reperfusion. Inhibitor of metalloproteinase can be the new target for the prevention and treatment of cerebral ischemia.
作者 涂悦 马铁柱 吴绘
机构地区 天津武警医学院附属医院脑系科中心
出处 《医学综述》 2006年第1期55-57,共3页 Medical Recapitulate
关键词 基质金属蛋白酶 基质金属蛋白酶抑制剂 脑缺血 Matrix metalloproteinase Inhibitor of metalloproteinase Cerebral ischemia
分类号 R743.3 [医药卫生—神经病学与精神病学]
  • 相关文献

参考文献22

  • 1Romanic AM, White RF, Arleth A J, et al, Matrix metalloproteinase expression increases after cerebral focal ischemia in rats : inhibition of matrix metalloproteinase-9 reduces infarct size [J]. Stroke, 1998,29 ( 5 ) :1020-1030.
  • 2Rosenberg GA, Estrada EY, Dencoff JE, Matrix metalloproteinases and TIMPSs are assaciated with blood-braln barrier opening after reperfusion in rat brain[J], Stroke, 1998,29(10) : 2189-2195.
  • 3Hashimoto T, Wen G, Lawton MT, et al, Abnormal expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in brain arteriovenous malformations [J]. Stroke, 2003,34(4) : 925-931.
  • 4Lee CZ, Xu B, Hashimoto T, et al, Doxycycline suppresses cerebral matrix metalloproteinase-9 and angiogenesis induced by focal hyperstimulation of vascular endothelial growth factor in a mouse model [J],Stroke,2004,35(7) : 1715-1719.
  • 5Newby AC. Dual Role of Matrix Metalloproteinases(Matfixins)in Intireal Thickening and Atherosclerotic Plaque Rupture[J]. Physiol Rev,2005.85( 1 ) : 1-31.
  • 6Axisa B, Loftus I, Ross Naylor A. Prospective, randomized, double-blind trial investigating the effect of Doxycyeline on matrix metalloproteinase expression within atherosclerotie carotid plaques [J]. Stroke, 2002, 33 :2858-2865.
  • 7Pfefferkom T, Rosenherg GA. Closure of the blood-brain barrier by matrix metallopmteinase inhibition reduces rtPA-mediated mortality in cerebral ischemia with delayed reperfuaion [J]. Stroke, 2003, 34 (8) :2025-2030.
  • 8Alvarez-Sabin J, Delgado P, Abilleira S, et al. Temporal profile of matrix metalloprateinases and their inhibitors after spontaneuus intraeerebral hemorrhage:relationship to clinical and radiological outcome [J].Stroke,2004,35(6) : 1316-1322.
  • 9Cunningham LA, Wetzel M, Rosenberg GA. Multiple roles for MMPsand TIMPSa in cerebral ischemia[J]. Glia, 2005,50(4) : 329-339.
  • 10Hea JH, Kim SH, Lee KY, et al. increase in plasma matrix metalloproteinase-9 in acute stroke patients with thrombolyaia failure[J]. Stroke,2003,34(6) :e48-50.

同被引文献40

  • 1胡园,袁默,刘屏,穆丽华,王虹.石菖蒲对血脑屏障超微结构及通透性的影响[J].中国中药杂志,2009,34(3):349-351. 被引量：58
  • 2邢影,徐忠信,莽靖,钱佳利.大鼠局灶性脑缺血-再灌注损伤血管内皮细胞生长因子表达的研究[J].中国危重病急救医学,2005,17(3):174-176. 被引量：17
  • 3谢英,杜熠,耿兴超,侯新朴.神经生长因子脂质体大鼠鼻腔给药的药效学研究[J].中国药学杂志,2005,40(10):742-746. 被引量：10
  • 4Enrique Zea Longa,Philip R. Weinstein,Sara Carlson,Robert Cummins.Reversible Middle Cerebral Artery Occlusion Without Craniectomy in Rats[J]Stroke,1989(1).
  • 5陈钢,侯世祥,胡平,金描真,刘军.经内耳途径靶向脑给药的初步研究[J].药学学报,2007,42(10):1102-1106. 被引量：16
  • 6Simon F. De Meyer,Guido Stoll,Denisa D. Wagner,Christoph Kleinschnitz.von Willebrand Factor: An Emerging Target in Stroke Therapy[J].Stroke.2012(2)
  • 7Nicole A. Terpolilli,Seong-Woong Kim,Serge C. Thal,Hiroharu Kataoka,Vilia Zeisig,Bjoern Nitzsche,Benjamin Klaesner,Changlian Zhu,Susanne Schwarzmaier,Lilja Meissner,Uta Mamrak,Doortje C. Engel,Alexander Drzezga,Rakesh P. Patel,Klas Blomgren,Henryk Barthel,Johannes Boltze,Wolfgang M. Kuebler,Nikolaus Plesnila.Inhalation of Nitric Oxide Prevents Ischemic Brain Damage in Experimental Stroke by Selective Dilatation of Collateral Arterioles[J].Circulation Research.2012(5)
  • 8Konopková, R,Vilagi, I,Borbely, S,Kubová, H,Otáhal, J.Effect of Endothelin-1 on the Excitability of Rat Cortical and Hippocampal Slices In Vitro[J].EN.2012(2)
  • 9Inan Olmez,Huseyin Ozyurt.Reactive oxygen species and ischemic cerebrovascular disease[J].Neurochemistry International.2011(2)
  • 10Koh-ichi Yuhki,Fumiaki Kojima,Hitoshi Kashiwagi,Jun-ichi Kawabe,Takayuki Fujino,Shuh Narumiya,Fumitaka Ushikubi.Roles of prostanoids in the pathogenesis of cardiovascular diseases: Novel insights from knockout mouse studies[J].Pharmacology and Therapeutics.2010(2)

引证文献4

二级引证文献35

医学综述
2006年 第1期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部