降纤酶的不良反应

Adverse Drug Reactions of Defibrase

目的:探讨降纤酶不良反应的一般规律和特点。方法:对1999年～2003年国内医药学术期刊报道的降纤酶不良反应案例进行统计、分析。结果:降纤酶所致不良反应主要有出血、荨麻疹、高热反应、皮肤试验阳性、肝功能损害、皮下血肿、血小板减少性紫癜、切口大出血以及动脉栓塞等。结论:临床应重视降纤酶的不良反应,以确保用药安全。

OBJECTIVE：To discuss the general pattern and features of adverse drug reactions（ADRs） of defibrase.METHODS： The cases of ADRs of defibrase reported in the national medical journals during 1999 and 2003 were collected and analyzed. RESULTS： ADRs of defibrase mainly included bleeding, urticaria, high fever, positive cutantest, liver function injury, ecchymoma, purpura haemorrhagica, incision hemorrhea, and arterial embolism .CONCLUSION： Great importance should be attached to ADRs of defribrase in clinic in order to ensure the safety of drug use.