长尾粗叶木根化学成分的研究Ⅰ

Chemical constituents from root of Lasianthus acuminatissimus Ⅰ

目的:研究茜草科粗叶木属植物长尾粗叶木Lasianthus acuminatissimus根中的化学成分。方法:利用正相、反相(RP-18)硅胶柱色谱、大孔树脂柱色谱和制备高效液相色谱分离,通过现代波谱技术(13C-NMR,1H-NMR,DEPT,EI-MS)鉴定结构。结果:分离鉴定了6个化合物,分别为:异东莨菪素(isoscopletinⅠ),异东莨菪素6-O-β-D-葡萄糖苷(isoscopletin-6-O-β-D-glucopyranosideⅡ),mudanoside-A的β构型体(Ⅲ),车叶草苷(asperulosideⅣ),(-)-pinoresinol 4-O-β-D-glucopyranoside(Ⅴ),胡萝卜苷(Ⅵ)。结论:这些化合物均是首次从粗叶木属植物中得到。

Objective： To investigate the chemical constituents from the root of Lasianthus acuminatissirmus of Rubiaceae. Method：Normal, reverse phase silica gel, macroporous resin column and HPLC chromatography were used for isolation. Spectroscopic methods （^13C-NMR,^1H-NMR, DEFt, EI-MS） were used for identification. Result： Six compounds were isolated and elucidated as isoscopletin （ Ⅰ ）, isoscopletin-6- O-β-D-glucopyranoside （ Ⅱ ）, β configuration of Mudanoside-A （Ⅲ ）, asperuloside （ Ⅳ ）, （ - ）-pinoresinol 4- O-β-D-glucopyra- noside （ Ⅴ）, daucosterol （ Ⅵ ）. Conclusion： These compounds were obtained from this plant for the first time.