供体淋巴细胞注射治疗恶性浆膜腔积液的临床研究

Treatment of malignant serosal effusion through injecting donor lymphocytes into serosal cavity

目的观察供体淋巴细胞注射治疗恶性浆膜腔积液的疗效及毒副作用。方法首先最大限度地排净浆膜腔积液,然后将采集的供体淋巴细胞经穿刺直接注入浆膜腔内。结果9例恶性浆膜腔积液患者中,显效5例,部分有效4例,总有效率100%。主要不良反应为发热和胸痛。结论供体淋巴细胞注射治疗恶性浆膜腔积液的疗效肯定,不良反应轻。

Objective To investigate the clinical efficacy and side effects of malignant serosal effusion through injecting donor lymphocytes into serosal cavity once for all. Methods First, the serosal effusion was drained thoroughly, then donor lymphocytes were injected into pleural cavity once for all. Results Nine cases of malignant serosal effusion were treated; significant effectiveness included five cases, partial effectiveness four cases. The effect rate was 100 %. The main side effects were fever and chest pain. Conclusion Treatment of malignant serosal effusion through injecting donor lymphocytes into serosal cavity once for all has definite effectiveness, with acceptable side eftects.