三维适形放射治疗联合羟基喜树碱治疗局部晚期非小细胞肺癌疗效分析

Application of 3-dimensional conformal radiotherapy combined with hydroxycamptothecin in the treatment of local advanced NSCLC

目的评价三维适形放射治疗(3DCRT)联合羟基喜树碱(HCPT)治疗局部晚期非小细胞肺癌(NSCLC)的价值。方法95例患者随机分为治疗组和对照组,治疗组采用3DCRT加H CPT全身化疗,对照组单用3DCRT。结果治疗组和对照组近期疗效(CR+PR)分别为73.4%,62%(P<0.001)。1,2年生存率分别为65%,26%和54%,22%(P<0.01),差异具有统计学意义。结论3DCRT可以提高肿瘤局部剂量和局控率,H CPT使放疗增敏,二者结合,是有效治疗NSCLC的方法。

Objective To evaluate the value of 3-dimensional conformal radiotherapy combined with Hydroxycamptothecin（HCPT） in the treatment of local advanced non-small cell lung cancer. Methods A total of 95 cases were enrolled and randomly assigned to treatment group and control group. The treatment group was treated with 3-dimensional conformal radiotherapy（3DCRT） combined with I-ICPT. The control group was treated with 3DCRT only. Results Response rate （CR＋PR） is respectively 73.4 % and 62 %. The response rate of treatment group is higher than that of control group（P 〈0.001）. The one year, two year survival rates of these two groups were 65 %, 26 % and 54 %, 22 % respectively（P 〈0.01 ） the efficacy difference was significant. Conclusions 3DCRT can improve local dose of tumor and the local control rate. HCPT can increase radiosensibility, and it is an important treatment of NSCLC with 3DCRT combined HCPT.