摘要
肺癌的侵袭和转移是个多步骤多基因参与的复杂过程,CD44V6是一种分布极为广泛的细胞表面跨膜糖蛋白,主要参与细胞与细胞、细胞与细胞外基质之间的特异性粘连过程。研究表明:CD44V6的高表达有助于肿瘤细胞获得转移潜能。MMPs是一大组金属离子依赖的蛋白酶,它能降解细胞外基质(extracellular matrix,ECM)中的各种蛋白成分。近年来的研究发现,MMPs在肿瘤侵袭转移中的作用,除了降解ECM以外,它还能促进肿瘤血管生成。联合检测这两个指标对判断肺癌的转移、病变后发展以及预后评估具有重要的意义。
The process of lung cancer invasion and metastasis consists of a complex series of multigene and multistep, CD44v6 is a broadly distributed transmembrane glycoprotein, which mainly participates in the specific adhesion process and plays an important role in cell-cell and cell-matrix interactions.The researches showed that the high expression of CD44v6 was helpful for metastasis ability of tumor cell. MMps is a groups of metal hydronium depend-proteinase, it exhibits proteolytic activity against components of the extracellular matrix （ECM）. The recent study indicated that MMps has been played important roles not only in degradation of ECM proteins, but also in the regulation of tumorigenesis. Combined with two marker might be an important significant to judge prognosis ,metastasis and development.
出处
《肿瘤研究与临床》
CAS
2006年第1期66-68,共3页
Cancer Research and Clinic
