甲地孕酮在鼻咽癌放化疗中的临床应用

Use of megestrol acetute to improve the quality of life in patients with naspopharyngeal carcinoma during chemotherapy and radiotherapy

目的比较甲地孕酮联合放化疗与单用放化疗治疗鼻咽癌在毒副反应及生活质量的区别。方法100例鼻咽癌随机分成两组:对照组和联合组,对照组先行卡铂、5-氟脲嘧啶方案化疗,再行60Co放疗;联合组的放化疗方法同治疗组,在放化疗同时每天口服甲地孕酮160mg,至治疗结束。结果联合组骨髓抑制、恶心呕吐,体重下降等反应较对照组轻,P<0.05。结论甲地孕酮联合放化疗治疗鼻咽癌,能减轻放化疗毒副作用,明显提高患者生活质量。

Objective To investigate the effect of Megestrol and radiotherapy.In patients with naspopharyngeal carcinoma acetate to improve quality of life by chemotherapy Methods 100 patients with naspopharyngeal carcinoma were randomly divide into two groups.The control group received routine chemotherapy and radiotherapy only.treatment group under went routine chemotherapy and radiotherapy combined with megestrol Acetate. Results the results showed megestrol acetate was able to reduce： nausea, vomiting, losing weight and lenkopenia caused by chemotherapy and radiotherapy （P〈0.05）.There were significant differences Between two group. Conclusions Use of Megestrol Acetute can reduce toxic-effect,improve the life quality of nasopharygeal carcinoma patients in chemotherapy and radiotherapy.