EB病毒-潜伏膜蛋白1致瘤机制的研究进展
摘要
EB病毒的感染与B细胞及上皮细胞来源的肿瘤密切相关,尤以致瘤基因潜伏膜蛋白1较为重要,其分子致瘤作用及机制的探讨一直是EB病毒致瘤机制研究领域中令人关注的焦点,而在临床上的应用也取得了颇具意义的进展。现就EB病毒-潜伏膜蛋白1致瘤的主要分子机制及进展作一综述。
出处
《国际检验医学杂志》
CAS
2006年第1期43-45,共3页
International Journal of Laboratory Medicine
参考文献12
-
1Tao Y,Song X,Deng X,et al.Nuclear accumulation of epidermal growth factor receptor and acceleration of G1/S stage by EpsteinBarr-encoded oncoprotein latent membrane protein 1.Exp Cell Res,2005,303(2):240-251.
-
2Tao YG,Tan YN,Liu YP,et al.Nuclear factor kappa B (NFkappaB) dependent modulation of Epstein-Barr virus latent membrane protein 1 (LMP1) in epidermal growth factor receptor (EGFR)promoter activity.Virus Res,2004,104(1):61-70.
-
3Eliopoulos AG,Stack M,Dawson CW,et al.Epstein-Barr virusencoded LMP1 and CD40 mediate IL-6 production in epithelial cells via an NF-kappaB pathway involving TNF receptor-associated factors.Oncogene,1997,14(24):2899-2916.
-
4Izumi KM,Kaye KM,Kieff ED.The Epstein-Barr virus LMP1 amino acid sequence that engages tumor necrosis factor receptor associated factors is critical for primary B lymphocyte growth transformation.Proc Natl Acad Sci USA,1997,94(4):1447-1452.
-
5Nitta T,Chiba A,Yamamoto N,et al.Lack of cytotoxic property in a variant of Epstein-Barr virus latent membrane protein-1 isolated from nasopharyngeal carcinoma.Cell Signal,2004,16 (9):1071-1081.
-
6Thompson MP,Aggarwal BB,Shishodia S,et al.Autocrine lymphotoxin production in Epstein-Barr virus-immortalized B cells:induction via NF-kappaB activation mediated by EBV-derived latent membrane protein 1.Leukemia,2003,17(11):2196-2201.
-
7杨力芳,王承兴,胡智,唐敏,顾焕华,翁新宪,易薇,曹亚.EB病毒LMP1通过NF-kB介导的HSV-tk/GCV治疗EBV相关肿瘤的研究[J].中国肿瘤生物治疗杂志,2002,9(4):237-242. 被引量:2
-
8Ardila Osorio H,Pioche-Durieu C,Puvion-Dutilleul F,et al.TRAF interactions with raft-like buoyant complexes,better than TRAF rates of degradation,differentiate signaling by CD40 and EBV latent membrane protein 1.Int J Cancer,2005,113(2):267-275.
-
9Zhang X,Uthaisang W,Hu L,et al.Epstein-Barr virus-encoded latent membrane protein 1 promotes stress-induced apoptosis upstream of caspase-2-dependent mitochondrial perturbation.Int J Cancer,2005,113(3):397-405.
-
10Shao JY,Ernberg I,Biberfeld P,et al.Epstein-Barr virus LMP1 status in relation to apoptosis,p53 expression and leucocyte infiltration in nasopharyngeal carcinoma.Anticancer Res,2004,24(4):2309-2318.
二级参考文献12
-
1潘雷 曹亚.EB病毒LMP1促进鼻咽癌中NF-κB表达的实验研究[J].中国耳鼻喉科颅底外科学杂志,1999,2(3):54-57.
-
2Singhal S. Cancer chemotherapy using suicide genes [ J ]. Surg Oncol Clin N Am, 1998, 7(3): 505-36.
-
3Loimas S, Toppinen MR, Visakorpi T, et al. Human prostate carcinoma cells as targets for herpes simplex virus thymidine kinasemediated suicide gene therapy[ J ]. Cancer Gene Ther, 2001, 8(2): 137-144.
-
4Bruder JT, Heidecker G, Tan TH, et al. Oncogene activation of HIV-LTR-driven expression via the NF-kappa B binding sites[ J]. Nucleic Acids Res, 1993, 21 (22): 5229-5234.
-
5廖伟 易红 曹亚 等.Tet—on调控的LMP1基因导入鼻咽癌细胞的研究[J].生物物理和生物化学学报,1999,31(3):256-260.
-
6Narita M, Bahar R, Hatano M, et al. Tissue-specific expression of a suicide gene for selective killing of neuroblastoma cells using a promoter region of the NCX gene[ J]. Cancer Gene Ther, 2001,8(12): 997-1002.
-
7Yu D, Chen D, Chiu C, et al. Prostate-specific targeting using PSA promoter-based lentiviral vectors[J]. Cancer Gene Ther, 2001,8(9): 628-635.
-
8Tanaka S, Iwai M, Harada Y, et al. Targeted killing of carcinoembryonic antigen (CEA)-producing cholangiocarcinoma cells by polyamidoamine dendrimer-mediated transfer of an Epstein-Barr virus (EBV) -based plasmid vector carrying the CEA promoter[ J ].Cancer Gene Ther, 2000, 7(9): 1241-1250.
-
9Cao G, Kuriyama S, Gao J, et al. Gene therapy for hepatocellularcarcinoma based on tumour-selective suicide gene-expression using the alpha-fetoprotein (AFP) enhancer and a housekeeping gene promoter[J]. Eur J Cancer. 2001,37(1): 140-147.
-
10Li JH, Chia M, Shi W, et al. Tumor-targeted gene therapy for nasopharyngeal carcinoma[ J]. Cancer Res, 2002, 62 ( 1 ): 171-178.
-
1何发尧.EB病毒编码LMP-1在鼻咽癌中的致瘤机制[J].国外医学(耳鼻咽喉科学分册),2003,27(2):95-97. 被引量:3
-
2谢发君,陈玮莹,温博贵.微卫星不稳定性与结肠癌的研究进展[J].癌变.畸变.突变,2007,19(1):82-84. 被引量:6
-
3齐宗利,赵彤,周新华,张进华,韩西群,朱梅刚.霍奇金淋巴瘤潜伏膜蛋白1、p53及bcl-2蛋白的表达及意义[J].第一军医大学学报,2003,23(3):225-227. 被引量:3
-
4成潇,江兴堂,尹小文.人乳头瘤病毒与肺癌关系的研究进展[J].国际呼吸杂志,2010,30(10):601-605.
-
5王玉彬.骨肉瘤中PTEN基因蛋白的表达及临床意义[J].山东医药,2004,44(36):44-44.
-
6孙晗笑,王声涌.人类疱疹病毒8的致瘤作用[J].生命的化学,1999,19(6):286-287. 被引量:3
-
7杨兰,孙振柱,李锋.HLA与HPV相关肿瘤的研究进展[J].国际病理科学与临床杂志,2006,26(4):321-324. 被引量:3
-
8任占平.人乳头瘤病毒感染与食管癌[J].右江民族医学院学报,1999,21(3):485-487.
-
9黄慧,曾华,杨文萍.伯基特淋巴瘤发病机制的研究进展[J].临床与实验病理学杂志,2015,31(1):72-74. 被引量:8
-
10翟长文,王纾宜.EB病毒与扁桃体淋巴瘤的相关性研究[J].国际病理科学与临床杂志,2012,32(3):236-243.