期刊文献+

DNA甲基化与基因沉默及肿瘤 被引量:12

下载PDF
导出
摘要 DNA甲基化在胚胎发育及肿瘤演变过程中都扮演了重要角色,相关方面的研究日益受到关注。现对近年来DNA甲基化的分子学基础及其与基因沉默和肿瘤关系的研究进行综述。
出处 《国际检验医学杂志》 CAS 2006年第1期52-54,57,共4页 International Journal of Laboratory Medicine
  • 相关文献

参考文献18

  • 1Jeltsch A.Beyond Watson and Crick:DNA methylation and molecular enzymology of DNA methyltransferases.Chembiochem,2002,3(4):274-293.
  • 2Cheng X,Roberts RJ.AdoMet-dependent methylation,DNA methyltransferases and base flipping.Nucleic Acids Res,2001,29(18):3784-3795.
  • 3Reik W,Dean W,Walter J.Epigenetic reprogramming in mammalian development.Science,2001,293(5532):1089-1093.
  • 4Rein T,DePamphilis ML,Zorbas H.Identifying 5-methylcytosine and related modifications in DNA genomes.Nucleic Acids Res,1998,26(10):2255-2264.
  • 5Okano M,Xie S,Li E.Cloning and characterization of a family of novel mammalian DNA (cytosine-5) methyltransferases.Nat Genet,1998,19(3):219-220.
  • 6Jones PA,Laird PW.Cancer epigenetics comes of age.Nat Genet,1999,21(2):163-167.
  • 7Tamura G,Yin J,Wang S,et al.E-Cadherin gene promoter hypermethylation in primary human gastric carcinomas.J Natl Cancer Inst,2000,92(7):569-573.
  • 8Clark SJ,Harrison J,Molloy PL.Sp1 binding is inhibited by (m)Cp (m)CpG methylation.Gene,1997,195(1):67-71.
  • 9Singal R,Ginder GD.DNA methylation.Blood,1999,93(12):4059-4070.
  • 10Ng HH,Zhang Y,Hendrich B,et al.MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex.Nat Genet,1999,23(1):58-61.

二级参考文献2

共引文献1

同被引文献142

引证文献12

二级引证文献20

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部