硒对小鼠过量碘性脂代谢紊乱的干预作用研究

Effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice

目的观察过量碘性脂代谢紊乱的适宜的硒干预剂量。方法80只Balbc小鼠分为8组:正常组、高碘组(饮水含碘3000μgL)和6个补硒组(饮水含碘3000μgL,硒分别为0.1、0.2、0.3、0.4、0.5、0.75mgL),共喂养16周。放射免疫法测定甲状腺激素水平,测定血清和肝脏甘油三酯、胆固醇含量。结果与正常组比较,高碘组血清总胆固醇、肝脏总胆固醇、甘油三酯升高,而补充0.2mgL硒组上述指标与正常组差异无显著性。结论补充0.2mgL硒可有效干预过量碘引起的脂代谢紊乱。

Objective To explore the effect of selenium supplement on the disordered lipid metabolism induced by the overdose of iodine in mice. Methods The 80 Balb/c mice were randomly divided into eight groups, the normal control group, the high iodine group（drunk the water containing iodine 3000μg/L） and six selenium groups （drunk the water containing iodine 3000μg/L and selenium 0. 1, 0. 2, 0. 3,0.4, 0. 5,0.75mg/L）. The total cholesterol and tfiglycefide in serum and liver were determined. Results The total cholesterol in serum, the total cholesterol and triglyeefide in liver of high-iodine group increased significantly compared with normal control group. There is no difference between normal control group and the group drunk the water contained 0.2mg/L selenium. Conclusion It suggests that it is an effective intervention dosage to drunk water containing 0.2mg/L selenium.