育龄妇女与儿童转铁蛋白受体的比较研究

Comparison of transferrin receptor between child-bearing period women and children

目的比较健康儿童和育龄妇女血浆转铁蛋白受体(TfR)、铁蛋白(SF)浓度及TfRSF比值,研究血浆TfR与其它铁营养状况评价指标的相关性。方法以3组健康人群(3～6岁学龄前女童109名,11～12岁青春前期女孩133名,20～45岁育龄妇女115名)为研究对象,比较各组血浆TfR、铁蛋白(SF)浓度及TfRSF比值,研究TfR与SF、血红蛋白(Hb)、总铁结合力(TIBC)及年龄相关性。结果血浆TfR浓度在学龄前女童最高,青春前期女孩次之,育龄妇女最低,分别为(23.34±6.78)、(21.33±5.30)和(19.86±4.83)nmolL。青春前期女孩的血浆SF浓度高于育龄妇女,育龄妇女高于学龄前女童,分别为(60.37±33.39)、(57.17±29.81)和(47.83±24.49)μgL。TfRSF比值在学龄前女童最高,青春前期女孩次之,育龄期妇女最低,分别为(0.72±0.83)、(0.48±0.47)、(0.47±0.37)。多元线性回归分析表明,SF、Hb、年龄对TfR有影响。结论血浆SF、Hb(即使SF、Hb在正常值范围内)及年龄均对TfR有影响,储备铁含量越低SF对TfR的影响越强。儿童血浆TfR含量高于成年人,表明儿童生理性储备铁含量低于成年人。

To compare plasma TfR, ferritin concentrations and their ratios in children and child-beating period women and look for correlation between TfR concentration and other measures of iron status. Methods Our study groups were healthy 3-6-year-old preschool girls （n = 109）, 11-12-year-old prepubertal girls （n = 133） and 20-45-year-old child- bearing period women（n = 115）. Plasma TfR concentration, SF concentration and TfR/SD were compared in different groups. The correlation of TfR and other indexes were studied. Results TfR concentrations were higer in preschool girls [ （23.34 ± 6.78）nmol/L]than in prepubertal girls[ （21,33 ± 5.30）nmol/L] and higher in prepubertal girls than in childbearing period women [ （ 19.86 ± 4.83 ） nmol/L]. SF concentrations were higher in prepubertal girls [ （60.37 ± 33.39） μg/ L] than in child-beating women [ （57.17 ± 29.81 ）μg/L]and higher in child-beating women than in preschool girls[ （47.83 ± 24.49）μg/L]. TfR/SF ration were hlger in preschool girls （0.72 ± 0.83 ） than in prepubertal girls （ 0.48 ± 0.47 ） and higher in prepubertal girls than in child-beating period women（0.47 ±0.37）. By multiple regression analysis, the predictors of TfR concentration were plasma ferritin, hemaglobin and age. Conclusion Plasma ferritin, Hb and age, even within the normal physiologic SF, Hb, influence TfR concentrations. The lower the iron stores, the stronger the influence of ferrifin on TfR, The TfR concentrations are higher in children than adults respongsing to physiologically low iron stores in children.