Tamm-Horsfall蛋白影响草酸钙结石形成的化学基础

Chemical basis of the effects of Tamm-Horsfall protein on the formation of calcium oxalate stones

TammHorsfall(TH)蛋白是人体尿液中含量最多的蛋白质,它可以促进或抑制草酸钙(CaOxa)结石的形成,这种双重作用取决于TH蛋白本身的结构、浓度和尿液环境等因素。本文从TH蛋白自身浓度、尿液pH、离子强度和金属离子、柠檬酸盐与TH蛋白的协同作用、TH蛋白对草酸钙晶体在肾上皮细胞粘附的影响等方面,系统讨论了TH蛋白影响草酸钙结石形成的化学基础,并比较了TH蛋白与其它同类蛋白的差异。

Tamm-Horsfall （TH） protein is the most abundant protein in human urine. It plays dual roles in the formation of calcium oxalate stones depending on its structure, concentration and urine properties. In this paper, the chemical basis of the effects of TH protein on the formation of cacium oxalate stones was systematically discussed in view of the concentration of TH protein, the urinary pH, ionic strength, metallic ions, the cooperative effect of citrate and TH protein, and the effect on the adhesion of calcium oxalate crystals to the renal cell membrane. The differentiation between TH protein and its analog was also comparatively discussed.