肝动脉栓塞化疗对大肝癌根治术后复发率及生存率的影响

Effects of transcatheter hepatic arterial chemoembolization on recurrence and survival rate following radical operation of large hepatocellular carcinoma

目的探讨肝动脉栓塞化疗对于预防原发性大肝癌根治术后复发的疗效。方法对1997年1月～2002年12月我院68例行大肝癌根治术的患者按术后是否行介入治疗分为TACE组(24例)和对照组(44例),对比分析两组患者术后1、2、3年的累积复发率和生存率。结果对68例原发性大肝癌行根治性切除后的患者,术后随访最长49个月。TACE组术后1、2、3年累积复发率分别为16.7%、34.3%、49.5%;1、2、3年的累积生存率分别为83.3%、70.2%、53.7%。对照组1、2、3年的累积复发率分别为36.4%、58.0%、68.5%;1、2、3年的累积生存率分别为63.6%、48.3%、25.3%,两组差异有显著性(P<0.05)。结论原发性大肝癌根治术后辅以介入治疗是预防肝癌术后复发的有效手段,能显著提高远期生存率。

Objective To explore the curative effects of TACE on the prevention the recurrence after radical resection of large heputocellular carcinoma. Methods From January 1997 to December 2002, 68 cases received radical resection of large hepatocellular carcinoma were divided into TACE group （24 cases） and control group （44 cases） and 1, 2 and 3 years cumulative recurrence rate and survival rate were analyzed comparatively. Results 1, 2 and 3 years recurrence rates of TACE group and control group were 16.7%, 34.3%, 49.5% and 36.4%, 58.0%, 68.5% respectively. And those of cumulative survival rates were 83.3%, 70.2%, 53.7% and 63.6%, 48.3%, 25.3% respectively. There was significant difference between two groups （P〈0.05）. Conclusion Adjuvant interventional therapy is an effective method for preventing the postoperative recurrence after radical resection of large hepatocellular carcinoma, and it can improve the longterm survival rate.