钠碘转运体抗体在自身免疫性甲状腺疾病中临床价值的初步探讨

Clinical Value of Antibodies to Human Sodium Iodide Symporter in Patients with Autoimmune Thyroid Disease

选择自身免疫性甲状腺疾病(ATD)患者241例,分为Graves病(GD)初发组(83例)、GD治疗组(58例)、GD缓解组(66例)、桥本甲状腺炎(HT)组(34例),采用酶联免疫吸附法(ELISA)检测钠碘转运体抗体(NIS-Ab)水平。结果显示:GD组和HT组患者NIS-Ab阳性率高于正常对照组(P<0.05),不同时期的GD患者NIS-Ab水平无明显差异(P>0.05)。表明:NIS-Ab可能在GD和HT的发病机制中起重要作用。

With the method of enzyme-linked immunosorbent assay （ELISA）, the antibodies to human sodium iodide symporter（NIS-Ab） were measured in 241 patients with autoimmune thyroid diseases （ATD）（ Graves＇ disease （GD） untreated 83 cases, GD treated 58 cases, GD remission 66 cases, and Hashimoto＇ s thyroiditis patients 34 cases）. The results were：the positive rate of NIS-Ab of GD and HT was higher than normal controls（ P 〈 0.05）, there was no significant difference among different state of GD（ P 〉 0.05）. Conclusions：the NIS-Ab may play an important role in the pathogenesis of ATD.