3β-羟基-5-雄甾烯-17β-羧酸的合成

Synthesis of 3β-Hydroxy-5-and Rostene-17β-Carboxylic Acid

以孕烯醇酮乙酸酯为原料经溴仿化反应制得3β-羟基-5-雄甾烯-17β-羧酸,研究了它的反应条件,反应温度为20℃,收率92.6%。

3β - Hydroxy - 5 - androstene - 17β - carboxylic acid was prepared from pregnenolone acetate by bromoform reaction. The reaction conditions was optimized,the yield is up to 92.6% when the templeture is 20℃.