血塞通注射液对肺心病急性加重期血液流变学的影响

Affection of Xuesaitong Injection on Hemorheologic Change of the Patients with Pulmonary Heart Disease at Acute Aggravate Stage

目的探讨慢性肺心病急性加重期使用血塞通治疗后血液流变学的改变。方法将42例慢性肺心病急性加重期患者随机分为治疗组和对照组,治疗组24例,对照组18例。治疗组在常规治疗基础上给予血塞通500mg,(用糖盐液稀释)静脉注射,每日1次,14天为一疗程,对照组按常规治疗。结果治疗组全血高切、低切还原粘度,全血低切相对粘度,血浆粘度,红细胞聚集指数等指标较治疗前明显下降,与对照组相比有显著差异。结论血塞通注射液可以有效地降低血粘度,减少红细胞聚集的功能,能降低肺心病肺小动脉压而有助于临床治疗,改善症状。

Objective To discuss the change of hemorheclogy of the patients with pulmonary heart disease at acute aggravate stage after the treatment with Xuesaiteng Injection. Methods 42 patients with pulmonary heart disease at acuted aggravate stage were randomly divided into 2 group ： 24 patients in treatment group and 18 patients in control group. The patients in treatment group, besides the routine treatment, received intravenous injection of 500rag of Xuesaitong Injection once a day, 14 days a course, while the patients in control group received only routine treatment. Results For treatment group, the high shear rate, low shear rate, the whole blood low shear relative viscosity, whole plasma viscosity, aggregation of RBC and other data decreased greatly after treatment and there was a significant difference from those of control group. Conclusions Xiesaitong Injection can effectively decrease plasma viscosity, hemagglutination and pulmonary arteriole pressure of pulmonary heart disease, it is helpful in clinical treatment and can improve the symptom of the patients.