蕈样肉芽肿的发病机制及治疗进展

Advances in the Research of Pathogenesis and Treatment of Mycosis Fungoides

蕈样肉芽肿的发病机制目前仍不清楚,近年来对蕈样肉芽肿皮肤淋巴细胞归巢机制、淋巴细胞凋亡异常以及基因异常的研究,为揭示蕈样肉芽肿发病以及治疗提供了一些新的观点。除传统的光化学疗法、放疗、化疗、体外光化学疗法外,维A酸类、干扰素、白介素2融合蛋白、重组白介素12、人源化单克隆抗体等免疫调节剂对早期蕈样肉芽肿有较好的疗效。

The pathogenesis of mycosis fungoides is unknown at present, Recently, studies on the homing mechanism of lymphoeytes to the skin as well as on the abnormality of lymphocytcs apoptosis and genes have provided new insights into the pathogenesis and therapy of myeosis fungoides, hi addition to traditional photochemotherapy, radiotherapy,chemothcrapy, and extracorporeal photochemotherapy, immunomodulators, such as tretinoins, interterferons, interleukin-2 fusion protein, recombinant interleukin 12 and humanized monoclonal antibody may have a gored therapeutic effect on the treatment of early stage mycosis fungoides.