特应性皮炎小鼠模型研究进展

Mouse Models for Atopic Dermatitis

特应性皮炎是一种困扰人类的慢性炎症性皮肤病,开发和确立动物模型对研究发病机制和开发药物有着重大意义。近几年,除了经典的NC/Nga鼠,人类还利用转基因和基因敲除技术及抗原建立了一系列特应性皮炎小鼠模型。这些模型的建立,为更深入地研究特应性皮炎提供了方便。

Atopic dermatitis（AD） is a chronic skin disease. The development and establishment of animal models is of great importance for the investigation of the pathogenesis and treatment of AD. Recently, in addition to NC/Nga mice, other mouse models for AD have been developed by gene knockouts, transgenes and haptens. These models will facilitate the research on AD.