某些四乙酸四氮杂环烷烃La^（3＋）、Gd^（3＋）络合物的合成

Synthesis of some lanthanide complexes with a tetraacetic tetraaza macrocyclic alkane

在ＫＯＨ存在下，１，４，７，１０－四氮杂环十二烷与溴乙酸发生Ｎ－羧甲基化反应，得Ｎ，Ｎ’，Ｎ”，Ｎ－四乙酸－１，４，７，１０－四氮杂环十二烷（ＤＯＴＡ，１），产率８８．１％。在Ｋ２ＣＯ３作用下，１，４，８，１１－四氮杂环＋四烷与溴乙酸苄酯进行反应，得Ｎ－乙酸苄酯衍生物，经Ｐｄ／Ｃ催化氢解生成Ｎ，Ｎ’，Ｎ”，Ｎ－四乙酸－１，４，８，１１－四氮杂环十四烷（ＴＥＴＡ，３），产率５６．０％。ＤＯＴＡ和ＴＥＴＡ分别与ＬａＣｌ３和ＧｄＣｌ３形成络合物，产率为６４．１％～７４．６％。

Tetraazacy clododecane-N, N', N', N,tetraacetic acid(DOTA, 1) was synthesized by N-carboxylmethylation of 1, 4, 7, 10-tetraazacyclododecane with bromoacetic acid in the presence of potassium hydroxide. The yield was 88. 1 %. 1, 4, 8, 11-Tetraazacyclotetradecane-N,N',N', N-tetraacetic acid (TETA,3) was synthesized by the hydrogenolysis of N-benzylacetate of tetraaza macrocylic alkane which was prepared by the alkylation of 1, 4, 8, 11-tetraazacyclotetradecane with benzyl 2-bromoacetate in the presence of potassium carbonate. The yield of 3 was56. 0%. Four lanthanide complexes with a tetraacetic tetraaza macrocyclic alkane were obtained from the reactions of 1 and/or 3 with LaCl3 and/or GdCl3. The yields were 64. 1 %～74. 6 %.